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Hypoglycemia and Glucagon

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...

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Updated: Apr 16, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

Reversible splenium diffusion weighted MRI changes associated with hypoglycemia.

¹University Hospital of Pointe-à-Pitre/CHU de Pointe-à-Pitre, Neurology Unit, Route de Chauvel 97139 Abymes, France.

Journal of Diabetes and Its Complications

|March 17, 2015

Summary

Hypoglycemia can mimic stroke symptoms. Transient MRI lesions in the corpus callosum splenium are linked to low blood sugar, requiring clinical awareness to prevent misdiagnosis.

Keywords:

Corpus callosum Diffusion weighted imaging (DWI)Hypoglycemia MRI Reversible lesions Splenium

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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

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Published on: August 14, 2019

Area of Science:

Neurology
Radiology
Endocrinology

Background:

Hypoglycemia, or low blood sugar, can present with neurological deficits that mimic cerebrovascular events.
Diffusion-weighted imaging (DWI) on Magnetic Resonance Imaging (MRI) is crucial for detecting early ischemic changes in the brain.

Observation:

Two distinct cases are presented where patients exhibited transient lesions.
These lesions were specifically located in the splenium of the corpus callosum.
The MRI findings were directly correlated with episodes of hypoglycemia.

Findings:

The study identified a specific pattern of transient MRI lesions in the splenium of the corpus callosum.
These reversible lesions were associated with severe hypoglycemia.
Diffusion-weighted imaging effectively visualized these transient abnormalities.

Implications:

Clinicians should consider hypoglycemia in the differential diagnosis of stroke-like presentations.
Awareness of these transient MRI findings can prevent misdiagnosis and unnecessary interventions.
This highlights the importance of metabolic screening in patients with unexplained neurological symptoms and specific MRI findings.