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[Benzodiazepines tolerance and dependence: a case report].

M A Bernik, C Gorenstein, S M Tavares

    AMB : Revista Da Associacao Medica Brasileira
    |October 1, 1989
    PubMed
    Summary

    This case report details benzodiazepine (BDZ) abuse and dependence, noting tolerance to some effects but not others. Withdrawal symptoms included intensified paranoid personality traits.

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    Area of Science:

    • Pharmacology
    • Psychiatry
    • Neuroscience

    Background:

    • Benzodiazepines (BDZs) are commonly prescribed for anxiety and insomnia.
    • Abuse and dependence on BDZs can lead to complex clinical presentations.
    • Understanding differential tolerance is crucial for managing BDZ use disorder.

    Observation:

    • A case of significant benzodiazepine abuse and dependence is presented.
    • The patient exhibited tolerance to psychomotor sedative effects of BDZs.
    • Memory impairment effects of BDZs were not associated with tolerance.

    Findings:

    • Differential tolerance to various benzodiazepine effects was observed.
    • A distinct withdrawal syndrome emerged upon cessation of benzodiazepines.
    • Paranoid personality traits were notably exacerbated during withdrawal.

    Implications:

    • This case highlights the variable development of tolerance to benzodiazepine effects.
    • It underscores the importance of recognizing diverse withdrawal symptoms, including psychological manifestations.
    • Findings may inform clinical management strategies for benzodiazepine dependence and withdrawal.

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