Related Experiment Video
Updated: Apr 16, 2026
2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia
Published on: June 22, 2013
Joint blood and cerebrospinal fluid suppression for intracranial vessel wall MRI
Jinnan Wang1, Michael Helle2, Zechen Zhou3
1Philips Research North America, Briarcliff Manor, New York, USA.
Insights
A new Delay Alternating with Nutation for Tailored Excitation (DANTE) technique improves magnetic resonance imaging (MRI) of intracranial vessel walls. This method enhances contrast between vessel walls and cerebrospinal fluid (CSF), aiding diagnosis.
Area of Science:
- Medical Imaging
- Neuroimaging
- Magnetic Resonance Imaging (MRI)
Background:
- Intracranial vessel wall imaging is crucial for diagnosing cerebrovascular diseases.
- Distinguishing vessel walls from surrounding cerebrospinal fluid (CSF) can be challenging in standard MRI.
- Improved contrast is needed for accurate characterization of intracranial arteries.
Purpose of the Study:
- To develop and evaluate a novel joint blood and CSF suppression technique for enhanced intracranial vessel wall MRI.
- To optimize the Delay Alternating with Nutation for Tailored Excitation (DANTE) prepulse for CSF suppression.
- To assess the impact of DANTE on vessel wall and CSF contrast in major intracranial arteries.
Main Methods:
- Optimized the DANTE prepulse sequence specifically for CSF suppression.
- Evaluated the technique in six patients and three healthy volunteers.
- Compared CSF suppression efficiency, lumen SNR, and wall-lumen CNR with and without DANTE.
Main Results:
- The optimized DANTE technique significantly improved intracranial vessel wall characterization.
- CSF to wall contrast improved by 28% (P < 0.001).
- DANTE significantly enhanced wall-lumen (P < 0.001) and wall-CSF (P < 0.001) contrast-to-noise ratios with minimal impact on static tissue contrast.
Conclusions:
- DANTE-prepared MR imaging significantly improves contrast between the vessel wall and CSF in major intracranial arteries.
- This technique shows potential for integration into multicontrast protocols for intracranial wall imaging.
- DANTE offers a valuable tool for more detailed and accurate assessment of intracranial vessel walls.
Purpose:
To develop and evaluate a joint blood and cerebrospinal fluid (CSF) suppression technique for improved intracranial vessel wall MR imaging.
Methods:
The Delay Alternating with Nutation for Tailored Excitation (DANTE) prepulse was specifically optimized for CSF suppression to improve vessel wall and CSF contrast. It was evaluated on six patients and three healthy volunteers. CSF suppression efficiency, lumen signal to noise ratio, and wall-lumen contrast to noise ratio were compared between images with and without DANTE in major intercranial artery segments. Contrast changes in tissues were also compared with evaluate the technique's compatibility with multicontrast imaging techniques.
Results:
The optimized DANTE images significantly improved intracranial vessel wall characterization on all images. Quantitatively, CSF to wall contrast improved by 28% (DANTE-VISTA 1.354 ± 0.216 versus VISTA 1.057 ± 0.13; P < 0.001). DANTE also significantly improved wall-lumen (10.55 ± 3.79 versus 9.34 ± 3.54; P < 0.001) and wall-CSF (4.62 ± 3.19 versus 0.78 ± 2.30; P < 0.001) contrast-to-noise ratios. DANTE prepared images were also found to make only minimal impact on static tissue contrast.
Conclusion:
DANTE prepared MR imaging can significantly improve contrast between the vessel wall and cerebral spinal fluid in major intracranial arteries, holding a good potential to be combined with multicontrast protocol for intracranial wall imaging.
More Related Videos
10:41Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
Published on: June 3, 2021
06:24Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo
Published on: July 8, 2025
