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Related Concept Videos

Infection01:20

Infection

14.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
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Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

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Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
605
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

5.0K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
5.0K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.7K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Related Experiment Video

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Protocol to Create Chronic Wounds in Diabetic Mice
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Protocol to Create Chronic Wounds in Diabetic Mice

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Approach to chronic wound infections.

D Leaper1, O Assadian2, C E Edmiston3

  • 1Institute of Skin Integrity and Infection Prevention, University of Huddersfield, Huddersfield, U.K.

The British Journal of Dermatology
|March 17, 2015
PubMed
Summary
This summary is machine-generated.

Infection significantly delays chronic wound healing, often due to biofilms. Topical antiseptics are more effective than antibiotics for managing wound infection and biofilms, reducing resistance risks.

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Area of Science:

  • Wound healing
  • Infectious disease
  • Antimicrobial resistance

Background:

  • Infection is a primary cause of delayed healing in chronic open wounds.
  • Biofilms complicate wound infection diagnosis and management, contributing to prolonged inflammation and delayed healing.
  • Systemic infection, sepsis, and multiple organ dysfunction syndrome are life-threatening risks of neglected chronic wound infections.

Purpose of the Study:

  • To review the role of infection and biofilms in chronic wound healing.
  • To evaluate the efficacy of topical antimicrobials (antiseptics) versus antibiotics in managing chronic wound infections.
  • To highlight the importance of controlling biofilms in chronic wound management.

Main Methods:

  • Literature review on chronic wound infection, biofilms, and antimicrobial treatments.
  • Analysis of the mechanisms of action for antiseptics and antibiotics.
  • Discussion of antimicrobial resistance trends and their implications for wound care.

Main Results:

  • Biofilms contribute to excessive inflammation and delayed healing in chronic wounds.
  • Topical antiseptics demonstrate effectiveness through multiple mechanisms, making resistance development unlikely.
  • Antibiotics should be reserved for severe infections due to rising antimicrobial resistance and a lack of new drug development.

Conclusions:

  • Controlling biofilms is crucial for effective chronic wound management.
  • Antiseptics are a preferred option for managing chronic wound infections and biofilms over antibiotics.
  • Further research with randomized controlled trials is needed to support the use of antiseptic dressings for biofilm prevention and management.