Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

391
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
391
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

896
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
896
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

851
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
851
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

794
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
794
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

360
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
360
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

2.8K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concurrent thalamic and cerebellar involvement in pediatric neuropsychiatric lupus: Expanding the radiologic spectrum.

Lupus·2026
Same author

A Podcast on Patient and Physician Perspectives on the Management of Endometriosis and Relugolix Combination Therapy.

Advances in therapy·2024
Same author

Sleep Disorders and Chronic Pain Syndromes in the Pediatric Population.

Seminars in pediatric neurology·2023
Same author

Preliminary exploration of a multidimensional sleep health composite in adolescent females with frequent migraine.

Headache·2023
Same author

Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation.

Orphanet journal of rare diseases·2023
Same author

Dots and spots: A retrospective review of T2-hyperintense white matter lesions in pediatric patients with and without headache.

Headache·2023

Related Experiment Video

Updated: Apr 16, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.9K

Migraine management in children.

Marcy Yonker1, Tara Mangum

  • 1Department of Neurology, Barrow Neurological Institute at Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ, 85016, USA, myonker@phoenixchildrens.com.

Current Neurology and Neuroscience Reports
|March 17, 2015
PubMed
Summary

Effective pediatric migraine management requires differentiating childhood migraine from adult presentations, recognizing specific migraine variants in children, and applying knowledge from both pediatric and adult treatment literature.

More Related Videos

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.4K
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

4.7K

Related Experiment Videos

Last Updated: Apr 16, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.9K
Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.4K
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

4.7K

Area of Science:

  • Pediatric Neurology
  • Headache Medicine

Background:

  • Migraine is a common neurological disorder affecting children and adolescents.
  • Childhood migraine presents differently than adult migraine, necessitating specialized management approaches.

Purpose of the Study:

  • To highlight the critical distinctions between pediatric and adult migraine.
  • To emphasize the importance of identifying childhood migraine variants.
  • To underscore the need for a comprehensive understanding of treatment literature for effective pediatric migraine management.

Main Methods:

  • Review of current pediatric and adult migraine literature.
  • Analysis of diagnostic criteria and clinical presentations specific to childhood migraine.
  • Synthesis of evidence-based treatment strategies for pediatric migraine.

Main Results:

  • Key differences in symptomatology and presentation exist between pediatric and adult migraines.
  • Specific migraine variants are prevalent in pediatric populations, requiring tailored diagnostic and therapeutic approaches.
  • Integrated knowledge of both pediatric and adult treatment guidelines is essential for optimal outcomes.

Conclusions:

  • Successful migraine management in children hinges on recognizing age-specific differences.
  • Accurate identification of childhood migraine variants is crucial for effective treatment.
  • Clinicians must leverage comprehensive knowledge from both pediatric and adult migraine literature to optimize patient care.