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Determination of pipothiazine in human plasma by reversed-phase high-performance liquid chromatography
D A Ogden1, A A McKechnie, D A Bolton
1Department of Pharmacy, Heriot-Watt University, Edinburgh, UK.
Abstract:
A method is described for the determination of pipothiazine in human plasma, based on reversed-phase HPLC. The method has been applied in a pharmacokinetic study of pipothiazine in six psychiatric patients receiving repeated depot intramuscular injections for six months. A number of compounds likely to be taken concurrently by patients were tested for potential to interfere with the assay. There was no evidence of "dose-dumping" in the period following injection. Comparison of the pharmacokinetic profiles after the first and sixth injections showed no evidence of drug accumulation.
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