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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Other Pulmonary Disorders01:17

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Methods for Detecting Cytotoxic Amyloids Following Infection of Pulmonary Endothelial Cells by Pseudomonas aeruginosa
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Common variable immunodeficiency and pulmonary amyloidosis: a case report.

Sevket Arslan1, Ramazan Ucar, Dudu Mehmet Yavsan

  • 1Meram Faculty of Medicine, Department of Clinical Immunology and Allergy, Necmettin Erbakan University, Konya, 42090, Turkey.

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Summary

Common variable immunodeficiency (CVID) rarely co-exists with secondary amyloidosis. This report details the first case of pulmonary hypertension caused by pulmonary amyloidosis in a CVID patient.

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Area of Science:

  • Immunology
  • Pulmonology
  • Cardiology

Background:

  • Common variable immunodeficiency (CVID) is a primary immune deficiency marked by hypogammaglobulinemia, recurrent infections, and risks of autoimmune disease and malignancy.
  • Secondary amyloidosis arises from chronic inflammatory conditions, with rare documented co-existence with CVID, particularly in patients with bronchiectasis.

Observation:

  • This study presents a rare case of a patient diagnosed with CVID.

Findings:

  • The patient developed pulmonary hypertension.
  • The pulmonary hypertension was secondary to pulmonary amyloidosis.

Implications:

  • This case highlights a novel complication of CVID and secondary amyloidosis.
  • Further research is needed to understand the link between CVID, amyloidosis, and pulmonary hypertension.