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Cord blood n-3 LC-PUFA is associated with adiponectin concentrations at 10 years of age

M Standl1, H Demmelmair2, B Koletzko2

  • 1Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|March 17, 2015
PubMed

Insights

Higher cord blood levels of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) and a lower n-6/n-3 ratio are linked to increased adiponectin concentrations in children. This suggests a potential role for early-life PUFA status in metabolic health.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Metabolic Health

Background:

  • An elevated n-6 to n-3 long-chain polyunsaturated fatty acid (LC-PUFA) ratio is a potential risk factor for obesity.
  • N-3 LC-PUFA may positively influence weight development by altering adiponectin concentrations.

Purpose of the Study:

  • To investigate the association between cord blood n-3 LC-PUFA concentrations and adiponectin levels at 10 years of age.
  • To examine the relationship between cord blood n-6/n-3 LC-PUFA ratio and adiponectin concentrations in childhood.

Main Methods:

  • Analysis of fatty acid composition in cord blood and at 10 years of age using gas chromatography in 237 children.
  • Measurement of adiponectin concentrations at 10 years of age.
  • Linear regression models assessed associations, adjusting for confounders and LC-PUFA percentages at 10 years.

Main Results:

  • Higher cord blood n-3 LC-PUFA concentrations were inversely associated with adiponectin levels at 10 years (p<0.01).
  • A lower cord blood n-6/n-3 LC-PUFA ratio was significantly associated with higher adiponectin concentrations at 10 years (p=0.03).
  • Cord blood n-6 LC-PUFA concentrations showed no significant association with adiponectin levels.

Conclusions:

  • Higher concentrations of n-3 LC-PUFA in cord blood are linked to higher adiponectin concentrations in childhood.
  • A lower n-6/n-3 LC-PUFA ratio at birth is associated with favorable adiponectin levels later in childhood.
  • Early-life PUFA status may play a role in adiponectin regulation and subsequent metabolic health.

Keywords:
AdiponectinChildrenCord bloodEpidemiologyFatty acidsPUFA

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