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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Pneumonia I: Introduction01:30

Pneumonia I: Introduction

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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Related Experiment Video

Updated: Apr 16, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

960

Pyoderma gangrenosum associated with solid organ malignancies.

Varun Shahi1, David A Wetter2

  • 1Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA.

International Journal of Dermatology
|March 17, 2015
PubMed
Summary
This summary is machine-generated.

Pyoderma gangrenosum (PG) can signal a recurrence of solid organ malignancy. This rare association suggests considering malignancy in patients with unexplained PG or a history of cancer.

Related Experiment Videos

Last Updated: Apr 16, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

960

Area of Science:

  • Dermatology
  • Oncology
  • Internal Medicine

Background:

  • Pyoderma gangrenosum (PG) is linked to systemic diseases like inflammatory bowel disease, inflammatory arthritis, and hematologic malignancies.
  • Literature on the association between PG and solid organ malignancy is sparse, primarily consisting of isolated case reports.

Purpose of the Study:

  • To investigate the relationship between pyoderma gangrenosum and solid organ malignancies.
  • To determine if pyoderma gangrenosum can indicate a recurrence or new diagnosis of solid organ malignancy.

Main Methods:

  • Retrospective review of five patients diagnosed with both pyoderma gangrenosum and solid organ malignancy between 1996 and 2013.
  • Analysis of the temporal relationship between the onset of PG and the diagnosis or recurrence of solid organ malignancy.

Main Results:

  • In five identified cases, pyoderma gangrenosum and solid organ malignancy occurred within a three-month interval.
  • The malignancies observed were breast carcinoma (three patients) and gastrointestinal carcinoma (two patients).
  • Pyoderma gangrenosum preceded, followed, or occurred synchronously with the malignancy in different patients; one patient experienced recurrent PG with a new diagnosis of metastatic rectosigmoid carcinoma.

Conclusions:

  • This study is the first to suggest that pyoderma gangrenosum onset may herald solid organ malignancy recurrence.
  • Recurrent pyoderma gangrenosum can be associated with solid organ malignancy.
  • Consider solid organ malignancy in patients presenting with pyoderma gangrenosum of unknown etiology or with a prior history of malignancy.