Correlation of manganese with thyroid function in females having hypo- and hyperthyroid disorders
Related Experiment Video
Updated: Apr 16, 2026
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Nusrat Shahab Memon1, Tasneem Gul Kazi, Hassan Imran Afridi
1National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan, nusrat.memon138@gmail.com.
Abstract:
The aim of present study was to compare the level of manganese (Mn) with thyroid functions, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxin (FT4) of females having hyper- (HPRT) and hypothyroid (HPOT) disorder. For comparative study, females of the same age group (16-30 years) having no thyroid disorders were selected as referents. The serum samples were acid digested prior to analysis by electrothermal atomic absorption spectrometry. The validity and accuracy of the methodology was checked by a certified sample. The resulted data indicated that the mean values of Mn in serum samples of females have hyperthyroidism was significantly higher than referent subjects (p < 0.01), while lower values of Mn was observed in serum samples of hypothyroid patients. The mean values of FT3 and FT4 were found to be lower while TSH higher is in HPRT patients than age-matched healthy control females (p = <0.01). The reverse resulted data of these thyroid hormones was observed in HPOT patients (0.003).
Related Concept Videos
01:20Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
01:18Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
01:27Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
01:23The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:31Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...