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Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients with Hyperuricemia -- The PUSH-PATH3 Study
Hong Meng1, Gang Liu1, Jianlong Zhai1
1From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
Objective:
To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia.
Methods:
Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid > 7 mg/dl).
Results:
Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p < 0.01) and serum creatinine by 0.17 mg/dl (p < 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status.
Conclusion:
Prednisone can be used safely in symptomatic HF patients with hyperuricemia.
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