Risk of hip fractures in men with alpha-blockers: a nationwide study base on claim registry
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Updated: Apr 16, 2026
Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
Published on: August 17, 2017
Gi-Hyeon Seo1, Young-Kyun Lee2, Yong-Chan Ha3
1Health Insurance Review and Assessment Service, Seoul, Korea.
Background:
Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database.
Methods:
We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR).
Results:
Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker.
Conclusions:
Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
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