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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

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[Diastolic heart failure and multimorbidity]

Rolf Wachter1

  • 1Klinik für Kardiologie und Pneumologie, Universitätsmedizin Göttingen.

Deutsche Medizinische Wochenschrift (1946)
|March 17, 2015
PubMed

Insights

Diastolic heart failure, a common cause of hospitalisation, involves increased left ventricular stiffness and filling pressures. Treating this condition is challenging due to numerous underlying pathophysiologic changes and prevalent comorbidities.

Area of Science:

  • Cardiology
  • Internal Medicine

Context:

  • Heart failure is a leading cause of hospitalization in Germany.
  • Diastolic heart failure (HFpEF) accounts for approximately 50% of all heart failure cases.
  • Characterized by increased left ventricular stiffness and filling pressures, particularly during exercise.

Purpose:

  • To discuss the pathophysiology of diastolic heart failure.
  • To highlight the prevalence and impact of comorbidities in diastolic heart failure.
  • To review therapeutic options for managing comorbidities in diastolic heart failure.

Summary:

  • Diastolic heart failure, or heart failure with preserved ejection fraction (HFpEF), results from increased left ventricular stiffness.
  • Numerous pathophysiologic changes contribute to HFpEF, complicating treatment strategies.
  • Comorbidities are more frequent in HFpEF than in heart failure with reduced ejection fraction (HFrEF) and significantly affect outcomes.

Impact:

  • Understanding the complex pathophysiology and comorbidities of diastolic heart failure is crucial for effective patient management.
  • This review provides insights into the prevalence, relevance, and therapeutic approaches for comorbidities associated with diastolic heart failure.
  • Improved management of comorbidities may lead to better outcomes for patients with diastolic heart failure.

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