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Updated: Apr 16, 2026
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
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Risk factors for progression in ADPKD.
1McGill University Health Centre, Montreal, Quebec, Canada.
Current Opinion in Nephrology and Hypertension
|March 17, 2015
Summary
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited kidney disorder. Recent trials show treatments can slow kidney volume growth and glomerular filtration rate decline in ADPKD patients.
Area of Science:
- Nephrology
- Genetics
- Internal Medicine
Background:
- Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent hereditary kidney disease.
- Disease progression is characterized by functional decline (glomerular filtration rate) and structural changes (kidney/cyst volume).
Purpose of the Study:
- To describe factors associated with ADPKD progression.
- To review clinical trial results impacting disease progression markers.
Main Methods:
- Review of prognostic factors for ADPKD.
- Analysis of recent clinical trial data on disease progression markers.
Main Results:
- Prognostic factors correlate with glomerular filtration rate decline and increased kidney/cyst volumes.
- Clinical trials demonstrate the ability to slow glomerular filtration rate decline and kidney volume growth in ADPKD.
Conclusions:
- Emerging therapies offer disease modification potential for ADPKD.
- Accurate identification of at-risk individuals is crucial for managing renal progression and complications.
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