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Updated: Apr 16, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Synthesis and complementary self-association of novel lipophilic π-conjugated nucleoside oligomers
J Camacho-García1, C Montoro-García, A M López-Pérez
1Nanostructured Molecular Systems and Materials Group, Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049, Madrid, Spain. david.gonzalez.rodriguez@uam.es.
Abstract:
A series of lipophilic nucleosides comprising natural and non-natural bases that are π-conjugated to a short oligophenylene-ethynylene fragment has been synthesized. These bases comprise guanosine, isoguanosine, and 2-aminoadenosine as purine heterocycles, and cytidine, isocytosine and uridine as complementary pyrimidine bases. The hydrogen-bonding dimerization and association processes between complementary bases were also studied by (1)H NMR and absorption spectroscopy in order to obtain the relevant association constants.
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