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Uncommon responses of segmental vitiligo to melanocyte-keratinocyte transplantation procedure
Prescilia Isedeh1, Ahmed Al Issa1, Henry W Lim1
1Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, MINational Center for Vitiligo & Psoriasis, Riyadh, Saudi ArabiaShetty Nursing Home, Mumbai, India.
Background:
Patients with segmental vitiligo (SV), unlike those with nonsegmental vitiligo (NSV), have a more predictable course and are more responsive to surgery.
Objective:
To report 10 patients with SV treated with the melanocyte-keratinocyte transplantation procedure (MKTP), who responded with unusual responses not previously reported in the literature.
Methods:
This is a retrospective, observational study that reports 10 patients with SV who underwent the MKTP between May 2003 and May 2012.
Results:
Two patients had successful repigmentation after split-thickness skin grafting after failure of the MKTP. Two patients developed a hypopigmented ring at a margin of the MKTP-treated area. One patient had complete repigmentation after a second MKTP. Two patients developed koebnerization of the recipient site. Three patients developed new vitiligo patches in previously unaffected areas after the MKTP.
Conclusions:
Uncommon and even suboptimal responses can occur following the MKTP in SV patients. There is a need for studies to provide better understanding and outcomes for SV patients undergoing the MKTP.
