Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...

Acne Infection

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Staphylococcal Skin Infections

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

Drugs for Treatment of Ulcerative Colitis in IBD

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Usefulness of a 'workplace prescription' as a resource for return-to-work.

Contact dermatitis·2023

Same author

Occupational contact dermatitis: Return to work using a multidisciplinary clinic model.

Contact dermatitis·2021

Same author

Commentary on "'Hypoallergenic', 'Sensitive Skin', and 'For Kids': Has industry improved labelling standards when it comes to sunscreens?"

Pediatric dermatology·2019

Same author

Sporobolomyces salmonicolor: A case report of a rare cutaneous fungal infection.

SAGE open medical case reports·2019

Same author

Introducing a "Workplace Prescription" to Facilitate Return to Work for Workers With Occupational Contact Dermatitis.

Journal of cutaneous medicine and surgery·2017

Same author

Borderline Lepromatous Leprosy: A Case to Remember.

Journal of cutaneous medicine and surgery·2016

Search research articles

Related Experiment Video

Updated: Apr 16, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Recall Dermatitis to Metronidazole.

Farheen Mussani¹, Sandy Skotnicki²

¹Division of Dermatology, University of Toronto, and Department of Occupational and Environmental Health, St. Michael's Hospital, Toronto, ON farheen.mussani@utoronto.ca.

Journal of Cutaneous Medicine and Surgery

|March 17, 2015

Summary

Recall dermatitis is a rare skin reaction that can occur after exposure to allergens or medications. This case highlights metronidazole as a potential trigger for recall dermatitis following both topical and oral use.

More Related Videos

Minimal Erythema Dose MED Testing

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Related Experiment Videos

Last Updated: Apr 16, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Minimal Erythema Dose MED Testing

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology
Pharmacology
Immunology

Background:

Recall dermatitis is an uncommon skin reaction.
It is associated with patch testing, repeated allergen exposure, and concurrent UV radiation and medication use.
Etiology of recall dermatitis from primary cutaneous and subsequent oral exposure is unknown.

Observation:

A case of recall dermatitis is presented.
The patient experienced a drug eruption secondary to metronidazole.
Metronidazole was initially used topically for rosacea, then orally for a gastrointestinal infection.

Findings:

Metronidazole exposure, both topical and oral, can precipitate recall dermatitis.
This case demonstrates a rare presentation of recall dermatitis.
The reaction occurred after sequential exposure routes.

Implications:

Clinicians should be aware of metronidazole's potential to cause recall dermatitis.
Consider recall dermatitis in patients with a history of metronidazole use presenting with skin eruptions.
Further research into the etiology of this phenomenon is warranted.