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[Ormond's disease complicated by infectious endocarditis]

V P Tiurin, T V Mezenova, V M Kitaev

    Klinicheskaia Meditsina
    |March 18, 2015
    PubMed

    Insights

    Retroperitoneal fibrosis, Ormond's disease, can lead to severe renal complications. This case highlights successful treatment of both Ormond's disease and antibiotic-resistant endocarditis using immunosuppressants and daptomycin.

    Area of Science:

    • Nephrology
    • Infectious Diseases
    • Cardiology

    Background:

    • Retroperitoneal fibrosis, also known as Ormond's disease, often presents late with renal complications.
    • Urinary tract infections can precipitate severe systemic conditions like endocarditis.

    Observation:

    • A patient with Ormond's disease developed infectious endocarditis caused by multidrug-resistant Enterococcus faecium.
    • The patient presented with advanced renal complications secondary to retroperitoneal fibrosis.

    Findings:

    • Combined therapy with moderate immunosuppression and daptomycin achieved remission.
    • Daptomycin demonstrated efficacy against the multidrug-resistant E. faecium strain.

    Implications:

    • This case suggests a potential therapeutic strategy for complex cases of retroperitoneal fibrosis with superimposed resistant infections.
    • Early diagnosis and multimodal treatment approaches are crucial for managing Ormond's disease and its complications.
    • Daptomycin may be a valuable option in treating resistant enterococcal endocarditis associated with fibrotic conditions.

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