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Characterization of effector components from the humoral and cellular immune response stimulated by melanoma cells

Chaobin Zhu1, Séverine Trabado2, Ye Fan1

  • 1Inserm U-1014, université Paris XI, groupe hospitalier Paul-Brousse, 94807 Villejuif cedex, France.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 18, 2015
PubMed

Modified melanoma B16 cells inhibited in their IGF-1 expression (B16MOD), on the contrary to the IGF-1 fully expressed parental wild-type (B16WT) counterpart, were shown to stimulate humoral as well as cellular immune responses. Among humoral components, the neutralizing and complement-fixing antibodies of IgM and essentially IgG2 (a+b) isotypes exhibited in vitro and in vivo effects upon tumour growth, while the IgG1 antibody isotype promoted enhanced tumour proliferation. As for the cellular immunity, it was found that the T CD8(+) lymphocyte subpopulation remained the main potent and long lasting immune active effector regulating tumour growth.

Keywords:
Humoral and cellular immune effectorsIGF-1 (insulin-like growth factor-1)Modified melanoma cells (B16MOD)Wild-type melanoma cells (B16WT)

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