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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates

Xavier Garrabou1, Tobias Beck, Donald Hilvert

  • 1Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich (Switzerland); Instituto de Química Avanzada de Cataluña-CSIC, Jordi Girona 18-26, 08034 Barcelona (Spain).

Angewandte Chemie (International Ed. in English)
|March 18, 2015
PubMed

Keywords:
asymmetric catalysisbiocatalysisdirected evolutionenzyme designenzyme promiscuity

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