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Sialic acids: biomarkers in endocrinal cancers
1School of Biological Sciences, National Institute of Science Education and Research (NISER), under Dept of Atomic Energy (DAE), Government of India, Institute of Physics Campus, Sachivalaya Marg, PO. Sainik School, Bhubaneswar, 751 005, India, sree.s@niser.ac.in.
Glycoconjugate Journal
|March 18, 2015
Summary
Altered sialylations, a type of protein modification, are linked to endocrine cancers. Sialic acids show promise as biomarkers for early detection and monitoring of these cancers.
Area of Science:
- Biochemistry
- Endocrinology
- Oncology
Background:
- Sialylations are crucial post-translational modifications involved in cellular recognition and signaling.
- Dysregulated sialylation pathways are implicated in various diseases, highlighting sialic acids as potential disease biomarkers.
- Endocrine disorders, particularly cancers, often lack effective early detection and monitoring markers.
Purpose of the Study:
- To review the role of sialic acids as biomarkers in endocrine disorders.
- To specifically evaluate sialic acids in the context of endocrine organ cancers.
- To explore the potential of targeting altered sialylation for endocrine cancer therapy.
Main Methods:
- Literature review focusing on studies of altered sialylations in endocrine cancers.
- Analysis of sialic acid expression in ovarian, pancreatic, thyroid, adrenal, and pituitary cancers.
- Consideration of limited data on testicular cancer.
Main Results:
- Altered sialylations are associated with endocrine organ cancers.
- Specific examples include altered sialylation in ovarian, pancreatic, thyroid, adrenal, and pituitary cancers.
- Data on sialic acid expression in testicular cancer is scarce.
Conclusions:
- Sialic acids are significant biomarkers for endocrine disorders and cancers.
- Targeting aberrant sialylation pathways presents a promising therapeutic strategy for endocrine cancers.
- Further research is needed, especially for testicular cancer.
