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Fatigue after stroke--perspectives and future directions.

Mansur A Kutlubaev1, Gillian E Mead, Anners Lerdal

  • 1Department of Neurology, G.G. Kuvatov's Republican Clinical Hospital, Ufa, Russia; Department of Neurology, Neurosurgery and Medical Genetics, Bashkir State Medical University, Ufa, Russia.

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PubMed
Summary

Post-stroke fatigue impacts recovery and may have subtypes, but its causes remain unclear. Promising management strategies include psychosocial interventions, physical activity, and mind-body approaches, though more research is essential.

Keywords:
: fatigabilityfatiguemanagementoutcomesrehabilitationstroke

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Psychology

Background:

  • Fatigue is a frequent and detrimental consequence following stroke.
  • The underlying mechanisms of post-stroke fatigue are not fully understood.
  • Potential subtypes like primary, secondary, subjective, and activity-dependent fatigue require further investigation.

Purpose of the Study:

  • To review the current understanding of post-stroke fatigue.
  • To explore potential subtypes and contributing factors.
  • To summarize evidence for management and treatment options.

Main Methods:

  • Literature review of existing research on post-stroke fatigue.
  • Analysis of psychological and biological factors associated with fatigue.
  • Evaluation of current and potential treatment strategies.

Main Results:

  • Post-stroke fatigue significantly impairs long-term outcomes.
  • Psychological and biological factors are implicated, but mechanisms are unclear.
  • Limited evidence exists for effective treatments, with psychosocial interventions and physical activity showing promise.

Conclusions:

  • Further research is crucial to elucidate the mechanisms and subtypes of post-stroke fatigue.
  • Psychosocial treatments, physical activity, mind-body interventions, and psychostimulants warrant further investigation for effective management.