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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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[Update on oncological pain in the elderly].

Luis Cabezón-Gutiérrez1, Javier Gómez-Pavón2, Javier Pérez-Cajaraville3

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Summary

Cancer pain significantly impacts geriatric patients, affecting quality of life and function. Effective diagnosis and multidimensional management are crucial for this vulnerable population.

Keywords:
Cancer pain assessmentCancer pain managementDolor oncológicoGeriatric cancer painGeriatric patientManejo del dolor oncológicoPaciente geriátricoValoración del dolor oncológico

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Area of Science:

  • Geriatric Medicine
  • Oncology
  • Pain Management

Background:

  • Pain affects up to 90% of geriatric patients with terminal cancer.
  • Inappropriate pain assessment and treatment are common in this population.
  • Untreated pain leads to depression, anxiety, isolation, sleep/appetite disturbances, and loss of function.

Purpose of the Study:

  • To review relevant studies on the diagnosis and management of cancer pain in geriatric patients.
  • To highlight the need for a multidimensional approach to pain in elderly cancer patients.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of studies focusing on cancer pain in the geriatric population.

Main Results:

  • Cancer pain is highly prevalent in elderly patients.
  • Multidimensional assessment and treatment are necessary.
  • Effective pain management is essential for maintaining quality of life and function.

Conclusions:

  • A comprehensive approach is vital for addressing cancer pain in geriatric patients.
  • Improved diagnostic and therapeutic strategies are needed.
  • Addressing pain can mitigate secondary symptoms and improve patient outcomes.