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IFITM3 rs12252 T>C polymorphism is associated with the risk of severe influenza: a meta-analysis

Y Xuan1, L N Wang1, W Li2

  • 1Key Laboratory of Environmental Medicine Engineering,Ministry of Education,Department of Epidemiology & Biostatistics,School of Public Health,Southeast University,Nanjing,China.

Epidemiology and Infection
|March 18, 2015
PubMed

Insights

The interferon-inducible transmembrane protein 3 (IFITM3) rs12252 T>C variant is linked to a higher risk of severe influenza. This genetic polymorphism increases susceptibility to severe illness but not initial infection.

Area of Science:

  • Immunogenetics
  • Viral Pathogenesis
  • Human Genetics

Background:

  • The interferon-inducible transmembrane protein 3 (IFITM3) is crucial for antiviral defense against influenza.
  • The IFITM3 rs12252 T>C polymorphism has been proposed to influence susceptibility to severe influenza.
  • Previous studies on this association yielded contradictory and inconclusive results.

Purpose of the Study:

  • To conduct a meta-analysis assessing the association between the IFITM3 rs12252 T>C polymorphism and the risk of severe influenza.
  • To clarify the conflicting findings regarding this genetic variant and influenza severity.

Main Methods:

  • A comprehensive literature search was performed across multiple databases (EMBASE, Pubmed, Web of Science, VIP, Wanfang, CNKI) up to August 1, 2014.
  • Four eligible studies, comprising 445 influenza patients and 3396 controls, were included in the meta-analysis.
  • Statistical analysis, including odds ratios (OR) and 95% confidence intervals (CI), was used to evaluate the associations.

Main Results:

  • A significant overall association was found between the IFITM3 rs12252 T>C polymorphism and influenza risk (e.g., C vs. T: OR 1.68, 95% CI 1.32-2.13).
  • Stratification by ethnicity revealed an increased influenza risk in Asians carrying the variant C allele (C vs. T: OR 1.88, 95% CI 1.34-2.62).
  • The variant C allele was significantly associated with an increased risk of developing severe influenza (C vs. T: OR 2.70, 95% CI 1.86-3.94), but not with mild infections.

Conclusions:

  • The IFITM3 rs12252 T>C polymorphism is significantly associated with an elevated risk of severe influenza.
  • This genetic variant does not appear to influence the risk of initial influenza virus infection.
  • The findings highlight the role of IFITM3 genetic variations in modulating influenza disease severity.
Keywords:
IFITM3influenzameta-analysispolymorphism

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