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Suplatast tosilate for treating cutaneous mastocytosis
Hiroki Yasudo1, Tomoaki Ando1,2, Mitsuteru Hiwatari1
1Department of Pediatrics, Graduate School of Medicine, Tokyo University, Tokyo, Japan.
Abstract:
Pediatric cutaneous mastocytosis is a rare disease caused by mast cell hyperplasia. We report the case of an infant diagnosed as cutaneous mastocytosis and seasonal allergies. The wheals, flushing, and pruritus of the mastocytosis were unresponsive to combination therapy with an antihistamine, a mast cell stabilizer (sodium cromoglycate), and a leukotriene antagonist. Addition of suplatast tosilate as a treatment for the seasonal allergy also dramatically improved his cutaneous symptoms and signs. Further trials of suplatast tosilate in selected cases of cutaneous mastocytosis are warranted.
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