Related Experiment Video
Updated: Apr 16, 2026
05:42
Author Spotlight: Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction
Published on: January 26, 2024
3.4K
Obesity and female malignancies
Chiara Benedetto1, Francesca Salvagno1, Emilie Marion Canuto1
1Obstetrics & Gynaecology I, Department of Surgical Sciences, University of Torino, Via Ventimiglia 3, 10133 Torino, Italy.
Best Practice & Research. Clinical Obstetrics & Gynaecology
|March 18, 2015
Summary
Obesity is linked to higher risks of several cancers, including endometrial, ovarian, and certain breast cancers, but inversely correlates with premenopausal breast cancer. Maintaining a healthy weight and regular screening are crucial for cancer prevention in women.
Area of Science:
- Oncology
- Endocrinology
- Public Health
Background:
- Obesity is a growing global health concern.
- It is associated with increased risks for several hormone-related cancers.
Purpose of the Study:
- To explore the complex relationship between obesity and various cancer types.
- To understand the mechanisms linking obesity to cancer development and progression.
- To provide recommendations for cancer prevention and management in obese individuals.
Main Methods:
- Review of existing epidemiological studies and biological mechanisms.
- Analysis of associations between Body Mass Index (BMI) and cancer incidence, recurrence, and mortality.
- Consideration of hormonal, metabolic, and inflammatory pathways.
Main Results:
- Obesity increases risk for endometrial, ovarian, ER+/PR+ postmenopausal breast, and cervical cancers.
- Inverse correlation found between BMI and premenopausal breast cancer.
- Obesity linked to higher cancer recurrence and mortality, potentially due to treatment and comorbidities.
Conclusions:
- Obesity influences cancer risk through hormonal, metabolic, and inflammatory pathways.
- Optimal cancer treatment in obese patients involves weight-based chemotherapy dosing and radical surgery.
- Lifestyle modification, weight loss, and regular screening are vital for cancer prevention in obese women.
Related Concept Videos
01:24Obesity
1.6K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.6K
01:24Disorders of the Female Reproductive System
4.9K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.9K
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
413
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
413
01:21Drug Dosing: Obese Patients
349
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
349
01:28Anorexia Nervosa
2.0K
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
2.0K
01:30Bulimia Nervosa
1.1K
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
1.1K