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Electrolyte changes after bowel preparation for colonoscopy: A randomized controlled multicenter trial.

Kyong Joo Lee1, Hong Jun Park1, Hyun-Soo Kim1

  • 1Kyong Joo Lee, Hong Jun Park, Hyun-Soo Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, South Korea.

World Journal of Gastroenterology
|March 18, 2015
PubMed
Summary
This summary is machine-generated.

Polyethylene glycol with ascorbic acid (PEG-Asc) bowel preparation offers improved patient satisfaction and willingness for repeat procedures compared to 4-L PEG, with similar efficacy and no electrolyte changes.

Keywords:
Ascorbic acidBowel preparationColonoscopyElectrolytePolyethylene glycol

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Area of Science:

  • Gastroenterology
  • Clinical Trials
  • Colorectal Cancer Screening

Background:

  • Colonoscopy requires effective bowel preparation for optimal visualization.
  • Traditional 4-L polyethylene glycol (PEG) solutions are effective but can be associated with poor palatability and patient tolerance.
  • Novel formulations aim to improve patient experience without compromising efficacy or safety.

Purpose of the Study:

  • To compare the efficacy and safety of 2-L PEG with ascorbic acid (PEG-Asc) versus 4-L PEG for bowel preparation.
  • To assess patient-reported outcomes, including symptoms, satisfaction, and willingness for repeat procedures.
  • To evaluate electrolyte balance following bowel preparation with both solutions.

Main Methods:

  • A multicenter, randomized trial involving 226 patients undergoing colonoscopy.
  • Patients were assigned to either PEG-Asc or 4-L PEG groups.
  • Bowel preparation quality was assessed using the Boston Bowel Preparation Scale (BBPS).
  • Patient-reported symptoms, satisfaction, and willingness for repeat preparation were collected via questionnaires.
  • Serum and urine electrolytes and osmolarity were measured before and after the procedure.

Main Results:

  • No significant difference in BBPS scores or adequate bowel preparation rates (≥6) between PEG-Asc and 4-L PEG groups (73.2% vs 76.3%, P=0.760).
  • PEG-Asc demonstrated significantly better taste (41.1% vs 16.7%, P<0.001) and higher willingness for repeat preparation (73.2% vs 59.3%, P=0.027).
  • No significant electrolyte or osmolarity changes were observed in either group.

Conclusions:

  • PEG-Asc provides comparable bowel preparation quality and safety profile to 4-L PEG.
  • PEG-Asc significantly enhances patient satisfaction and willingness for future bowel preparations.
  • This suggests PEG-Asc is a favorable alternative for improving patient adherence to colonoscopy preparation protocols.