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Compositional Differences of Ojeok-san (Wuji-san) Decoctions Using Pressurized or Non-pressurized Methods for
Jung-Hoon Kim1, Chang-Seob Seo1, Seong-Sil Kim1
1Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon, Korea.
Non-pressurized extraction for longer durations yielded higher Ojeok-san (Wuji-san) extract and soluble solids. Extraction time and method significantly impacted the final compound composition of the herbal decoction.
Area of Science:
- Herbal Medicine
- Pharmacognosy
- Traditional Chinese Medicine
Background:
- Ojeok-san (Wuji-san) is a traditional herbal formula.
- Optimizing extraction methods is crucial for maximizing therapeutic compound yield.
Purpose of the Study:
- To compare the effects of pressurized and non-pressurized extraction methods on Ojeok-san (Wuji-san) decoction composition.
- To investigate the influence of variable extraction times (60, 120, 180 minutes) on decoction characteristics.
Main Methods:
- Extraction of Ojeok-san (Wuji-san) under pressurized and non-pressurized conditions.
- Analysis of extract yield, total soluble solids, pH, and reference compound content.
Main Results:
- Non-pressurized extraction yielded higher extract and soluble solids, increasing with time.
- pH decreased with extended extraction time for both methods.
- Non-pressurized extraction favored higher levels of specific compounds (albiflorin, paeoniflorin, etc.) at 60 and 180 minutes.
- Pressurized extraction showed higher cinnamaldehyde at 120 minutes.
- Non-pressurized decoctions showed increased levels of multiple compounds with longer extraction times.
Conclusions:
- Extraction method and time significantly alter the phytochemical profile of Ojeok-san (Wuji-san) decoctions.
- Non-pressurized extraction appears more effective for maximizing overall yield and certain key compounds.
- Further research can optimize extraction parameters for specific therapeutic goals.
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