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Toward multifunctional "clickable" diamond nanoparticles.

Manakamana Khanal1, Volodymyr Turcheniuk1,2,3, Alexandre Barras1

  • 1†Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, Université Lille 1, Cité Scientifique, 59655 Villeneuve d'Ascq, France.

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Summary

Researchers developed multifunctional nanodiamonds (NDs) for biomedical use. These NDs offer water solubility and enable further modification via click chemistry, paving the way for advanced nanomaterials.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Nanodiamonds (NDs) are promising carbon-based nanomaterials for biomedical applications.
  • Simultaneous integration of multiple functions onto NDs is crucial for advanced applications.
  • Current methods for ND functionalization require optimization for multifunctionality.

Purpose of the Study:

  • To develop a multifunctional nanodiamond formulation with orthogonal surface modification.
  • To enable simultaneous integration of water-solubilizing and click chemistry-reactive groups onto NDs.
  • To demonstrate the utility of the functionalized NDs for further ligand attachment.

Main Methods:

  • Orthogonal surface modification of hydroxylated nanodiamonds using dopamine anchors.
  • Stoichiometrically controlled integration of triethylene glycol (EG) and azide (-N3) functionalities.
  • Post-synthetic modification of azide-functionalized NDs using copper-catalyzed azide-alkyne cycloaddition (click chemistry).

Main Results:

  • Successfully fabricated NDs simultaneously functionalized with EG and -N3 groups.
  • EG functionalities conferred water and biological media solubility to the NDs.
  • -N3 groups enabled efficient postsynthetic attachment of alkynyl-terminated ligands via click chemistry.

Conclusions:

  • The proposed strategy allows for the creation of multifunctional nanodiamonds with tailored properties.
  • This approach provides a versatile platform for developing advanced nanodiamond-based biomedical materials.
  • The developed formulation enhances the applicability of nanodiamonds in biological and medical fields.