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Updated: Apr 16, 2026

Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
Published on: April 24, 2020
A new technology for applanation free corneal trephination: the picosecond infrared laser (PIRL)
Stephan J Linke1, Andreas Frings2, Ling Ren3
1Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE), Martinistrasse 52, 20246, Hamburg, Germany; CareVision/Clinica Baviera Germany and Austria, Martinistrasse 52, 20246, Hamburg, Germany.
Abstract:
The impact of using a Femtosecond laser on final functional results of penetrating keratoplasty is low. The corneal incisions presented here result from laser ablations with ultrafast desorption by impulsive vibrational excitation (DIVE). The results of the current study are based on the first proof-of-principle experiments using a mobile, newly introduced picosecond infrared laser system, and indicate that wavelengths in the mid-infrared range centered at 3 μm are efficient for obtaining applanation-free deep cuts on porcine corneas.

