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Related Experiment Videos

Myosin: a link between streptococci and heart.

K Krisher, M W Cunningham

    Science (New York, N.Y.)
    |January 25, 1985
    PubMed
    Summary

    Streptococcus pyogenes antibodies cross-react with human heart myosin, suggesting shared molecular structures. This finding may explain autoimmune responses in certain streptococcal infections.

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    Autoimmunity·2002

    Area of Science:

    • Immunology
    • Molecular Biology
    • Cardiology

    Background:

    • Streptococcus pyogenes infections can trigger autoimmune conditions.
    • Molecular mimicry is a proposed mechanism for autoimmune responses.
    • Skeletal and cardiac muscle proteins share similarities.

    Purpose of the Study:

    • To investigate potential cross-reactivity between Streptococcus pyogenes and human cardiac myosin.
    • To explore the role of molecular mimicry in post-streptococcal autoimmunity.

    Main Methods:

    • Murine monoclonal antibodies were generated against Streptococcus pyogenes.
    • Immunological assays were performed to detect antibody binding to skeletal muscle myosin and human heart tissue proteins.
    • Adsorption experiments were used to confirm antibody specificity.

    Main Results:

    • Monoclonal antibodies to Streptococcus pyogenes demonstrated reactivity with skeletal muscle myosin.
    • Proteins in human heart tissue extracts cross-reacted with both S. pyogenes antibodies and antibodies to ventricular myosin.
    • Adsorption of antibodies with S. pyogenes removed their reactivity for both the bacteria and myosin.

    Conclusions:

    • Myosin, a cardiac muscle protein, shares common immunodeterminants with a component of Streptococcus pyogenes.
    • This molecular mimicry may contribute to the pathogenesis of autoimmune diseases following S. pyogenes infections.

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