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Related Experiment Video

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Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
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Bioactive triterpenoids from Atriplex lasiantha.

Basharat Ali1, Rehana Tabassum, Naheed Riaz

  • 1a Department of Chemistry , Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.

Journal of Asian Natural Products Research
|March 19, 2015
PubMed
Summary
This summary is machine-generated.

Researchers isolated a new triterpenoid from Atriplex lasiantha, along with two known compounds. These compounds showed promising antibacterial, antioxidant, and antiurease activities, with one isolate effective against E. coli.

Keywords:
Atriplex lasianthabiological activitiescharaterizationtriterpenoid

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Medicinal Plant Research

Background:

  • Atriplex lasiantha is a plant species with potential medicinal properties.
  • Triterpenoids are a class of natural compounds known for diverse biological activities.

Purpose of the Study:

  • To isolate and characterize compounds from Atriplex lasiantha.
  • To evaluate the antibacterial, antioxidant, and antiurease activities of the isolated compounds.

Main Methods:

  • Chromatographic purification of plant extracts.
  • Structure elucidation using Nuclear Magnetic Resonance (NMR) spectroscopy and high-resolution mass spectrometry.
  • In vitro assays for antibacterial, antioxidant, and antiurease activities.

Main Results:

  • A new triterpenoid (1) and two known triterpenoids (2, 3) were isolated.
  • Compound 2 showed significant antibacterial activity against Escherichia coli (IC50 = 66.25 μg/ml).
  • All compounds (1-3) demonstrated antioxidant (IC50 = 68.7-75.4 μg/ml) and antiurease (IC50 = 25.5-49.3 μg/ml) activities.

Conclusions:

  • Atriplex lasiantha is a source of bioactive triterpenoids.
  • The isolated compounds possess potential for development as antibacterial, antioxidant, and antiurease agents.