The psychological impact of false positive elevations of maternal serum alpha-fetoprotein

The purpose of this study was to assess the psychological impact of maternal serum alpha-fetoprotein screening on pregnant women with false positive elevations of maternal serum alpha-fetoprotein and on their male partners. Subjects with maternal serum alpha-fetoprotein elevations and their partners exhibited significantly heightened anxiety as measured by the State-Trait Anxiety Inventory following notification of the elevation, and this anxiety persisted until normal results were obtained by further testing. Heightened anxiety was not alleviated by counseling prior to definitive testing. Once normal results were obtained, anxiety returned to control levels and heightened anxiety was not observed throughout the remainder of pregnancy. Maternal serum alpha-fetoprotein elevations had little effect on maternal attitudes toward pregnancy as measured by the Maternal Attitudes to Pregnancy Inventory. Similarly, no differences were observed between subjects with normal and elevated maternal serum alpha-fetoprotein levels with regard to depression, marital discord, work attendance, or work productivity.