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Related Experiment Videos

Methadone for Fun Sake… Kidneys Are at Stake!!!

Sameer Chaudhari1, Kashmira Wankhedkar, Beata Popis-Matejak

  • 11Department of Cardiology, Newark Beth Israel Medical Center, Newark, NJ; and 2Department of Internal Medicine, Metropolitan Hospital Center, New York, NY.

American Journal of Therapeutics
|March 19, 2015
PubMed
Summary

Methadone use can lead to rhabdomyolysis, a condition causing kidney failure. This rare complication, requiring dialysis, highlights the need for clinician awareness in opiate dependence treatment.

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Area of Science:

  • Nephrology
  • Toxicology
  • Pharmacology

Background:

  • Rhabdomyolysis is a known cause of acute kidney injury.
  • Methadone is increasingly used for opiate dependence treatment.

Observation:

  • This case presents rhabdomyolysis exclusively caused by methadone ingestion.
  • The condition necessitated hemodialysis.

Findings:

  • Methadone can induce rhabdomyolysis through mechanisms similar to other opiates.
  • This complication is rare but potentially life-threatening.

Implications:

  • Clinicians must be aware of methadone-induced rhabdomyolysis.
  • Monitoring for this adverse effect is crucial in patients on methadone therapy.

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