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Familial exercise-induced anaphylaxis.

J A Grant, J Farnam, R A Lord

    Annals of Allergy
    |January 1, 1985
    PubMed
    Summary
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    This study investigated exercise-induced symptoms in a familial case, revealing elevated histamine and complement component (C2, C5) reductions during exertion, suggesting a non-allergic physiological response.

    Area of Science:

    • * Physiology
    • * Immunology
    • * Exercise Science

    Background:

    • * A familial history of exercise-induced cutaneous and cardiorespiratory symptoms was observed in an 18-year-old Hispanic male and his relatives.
    • * Symptoms manifested around 10 years of age during vigorous physical activity.

    Observation:

    • * The patient underwent maximal exercise and hot water immersion challenges.
    • * No allergic reactions were observed during these challenges.
    • * Plasma histamine levels increased significantly, from undetectable to 1.0 ng/ml and 3.7 ng/ml, respectively.

    Findings:

    • * Plasma histamine levels rose significantly during exercise and heat exposure.
    • * Complement components C2 and C5 were significantly reduced during exercise.

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  • * These findings suggest a physiological response rather than an allergic one.

    • Implications:

    • * The study highlights a potential non-allergic mechanism for exercise-induced symptoms involving histamine release and complement system activation.
    • * Understanding these physiological responses is crucial for accurate diagnosis and management of individuals with similar conditions.
    • * Further research into the specific triggers and pathways involved in this familial condition is warranted.