AIMing towards improved antitumor efficacy
Matthew J Weaver1, Alison K Kearns1, Sascha Stump1
1Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, United States.
Abstract:
Using the structure-activity relationship emerging from previous Letter, and guided by pharmacokinetic properties, new AIMs have been prepared with both improved efficacy against human glioblastoma cells and cell permeability as determined by fluorescent confocal microscopy. We present our first unambiguous evidence for telomeric G4-forming oligonucleotide anisotropy by NMR resulting from direct interaction with AIMs, which is consistent with both our G4 melting studies by CD, and our working hypothesis. Finally, we show that AIMs induce apoptosis in SNB-19 cells.
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