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Updated: Apr 16, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
Focus issue: noncoding RNAs in cancer
1Associate Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA. lferrare@aaas.org.
Abstract:
Through various means, noncoding RNAs regulate the expression of genes, many of which are associated with cellular homeostasis. Noncoding RNAs--especially microRNAs--are critical regulators of the mechanisms underlying numerous processes in cell biology, particularly those involved in the development and progression of cancer. This special issue of Science Signaling sheds light on the physiological and pathophysiological functions of this distinct class of molecules.
Insights
Noncoding RNAs, particularly microRNAs, are key regulators of gene expression impacting cellular balance. This research explores their roles in cell biology, especially in cancer development and progression.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- Noncoding RNAs (ncRNAs) are crucial for gene expression regulation.
- ncRNAs, especially microRNAs, play significant roles in cellular homeostasis.
- Dysregulation of ncRNAs is implicated in various diseases, including cancer.
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