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Published on: September 5, 2017
Unusual soft tissue infiltrates with 18F-FDG uptake in a patient with hairy cell leukemia
Glenna Gibson1, Jerome Lai, Paul Thomas
1From the *Specialised PET Services Queensland, Royal Brisbane and Women's Hospital, Brisbane; †Pathology Queensland, Sunshine Coast; ‡Department of Nuclear Medicine, Royal Brisbane and Women's Hospital; and §Faculty of Medicine and Biomedical Science, University of Queensland, Brisbane, Queensland, Australia.
Abstract:
Hairy cell leukemia (HCL) is an uncommon B-cell lymphoproliferative disorder, representing approximately 2% of leukemias. Diagnostic features include pancytopenia, splenomegaly, bone marrow reticulin fibrosis, and circulating hairy cells. Less commonly, there may be involvement of the liver and lymph nodes. We present a case of a 53-year-old man with HCL who was found to have soft tissue masses within the mediastinum and neck during pretreatment workup. An F-FDG PET/CT scan was requested to assess these lesions before treatment. These extensive infiltrates were FDG avid, and core biopsy of the mediastinal tissue was undertaken. Results were consistent with HCL.
