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Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes: a

Giovanni Vinetti1, Chiara Mozzini2, Paolo Desenzani3

  • 1Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Scientific Reports
|March 19, 2015
PubMed

Insights

Supervised exercise training (SET) significantly improved cardiorespiratory fitness, reduced cardiometabolic risk, and lowered oxidative stress in men with type 2 diabetes mellitus (T2DM) over 12 months.

Area of Science:

  • Exercise Physiology
  • Metabolic Health
  • Oxidative Stress Research

Background:

  • Type 2 diabetes mellitus (T2DM) is associated with impaired cardiorespiratory fitness, elevated cardiometabolic risk, and increased oxidative stress.
  • Lifestyle interventions, including exercise, are crucial for managing T2DM complications.

Purpose of the Study:

  • To evaluate the impact of a 12-month supervised exercise training (SET) program on cardiometabolic risk factors, cardiorespiratory fitness, and oxidative stress markers in male T2DM patients.

Main Methods:

  • Twenty male T2DM patients were randomized into SET and control groups. SET involved aerobic, resistance, and flexibility training.
  • Cardiorespiratory fitness (V'O₂max, gas exchange threshold), anthropometric measures, biochemical markers (lipids, insulin, HOMA-IR), and oxidative stress markers (POVPC, PGPC) were assessed at baseline and 12 months.

Main Results:

  • SET significantly improved V'O₂max (+14.4%) and gas exchange threshold (+23.4%).
  • SET reduced waist circumference (-1.4%), total cholesterol (-14.6%), LDL cholesterol (-20.2%), fasting insulinemia (-48.5%), and HOMA-IR (-52.5%).
  • SET significantly decreased plasma POVPC (-27.9%) and PGPC (-31.6%), normalizing levels compared to healthy controls post-intervention.

Conclusions:

  • Supervised exercise training is an effective intervention for improving cardiorespiratory fitness in T2DM.
  • SET positively impacts cardiometabolic risk factors and reduces oxidative stress in individuals with T2DM.
  • The findings support the integration of comprehensive SET programs into T2DM management strategies.

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