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Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
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Circulating adhesion molecules and arterial stiffness.

I D Kilic1, G Findikoglu2, Y I Alihanoglu3

  • 1Department of Cardiology, Medical Faculty, Pamukkale University, Denizli, Turkey. idogukilic@gmail.com.

Cardiovascular Journal of Africa
|March 19, 2015
PubMed
Summary
This summary is machine-generated.

This study found no correlation between levels of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) and aortic stiffness in patients. Therefore, these adhesion molecules may not serve as reliable biomarkers for aortic stiffness.

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Area of Science:

  • Cardiovascular Medicine
  • Biomarker Research
  • Adhesion Molecule Biology

Background:

  • Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) are key adhesion molecules in cardiovascular disease.
  • Previous studies have explored their potential as diagnostic and prognostic biomarkers, yielding inconsistent results.

Purpose of the Study:

  • To investigate the relationship between circulating VCAM-1 and ICAM-1 levels and aortic stiffness.
  • To assess the utility of these adhesion molecules as potential biomarkers for aortic stiffness in patients undergoing echocardiography.

Main Methods:

  • Echocardiography was used to determine aortic distensibility in 63 patients.
  • Serum concentrations of VCAM-1 and ICAM-1 were measured using enzyme immunoassay kits.

Main Results:

  • No significant correlation was found between VCAM-1 and ICAM-1 levels and indices of aortic stiffness.
  • Circulating levels were VCAM-1: 12.604 ± 3.904 ng/ml and ICAM-1: 45.417 ± 31.429 ng/ml in the study cohort.

Conclusions:

  • The role of soluble adhesion molecules in cardiovascular disease remains unclear.
  • Circulating VCAM-1 and ICAM-1 levels do not appear to be reliable markers of aortic stiffness in this patient population.