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Updated: Apr 16, 2026

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Published on: June 21, 2018
Genetic association between leptin-2548G/A polymorphism and risk of cancer: a meta analysis
Yugang Liu1, Hongyan Wu2, Yanpeng Zhu3
1Department of Orthopaedics, 401 Hospital of PLA Qingdao 266071, Shandong Province, China.
Objective:
Abundance of evidence implicated that leptin may play a decisive role in cancer occurrence, but the reported results varied across the individually published studies. The objective of this study is to access to what extent the extensively studied -2548G/A polymorphism of LEP gene acts on the onset of multiple cancers.
Methods:
Eligible studies included in this meta-analysis were identified electronically in PubMed and Embase, and manually in relevant literature. Crude odds ratio (OR) with corresponding 95% confidence interval (CI) was calculated to estimate the risk of cancer associated with the -2548G/A polymorphism.
Results:
12 association studies with a total of 5,618 cancer cases and 6,509 healthy controls were pooled into this meta-analysis. The results revealed that compared with the G allele, the A allele was associated with modestly increased risk of overall cancer (OR, 1.21; 95% CI, 1.02-1.44). Following further stratified analyses, a borderline association was indicated in prostate cancer (OR, 1.18; 95% CI, 1.00-1.39), breast cancer (OR, 1.11; 95% CI, 1.00-1.22) and Caucasians (OR, 1.19; 95% CI, 1.00-1.41).
Conclusions:
This meta-analysis reveals that the A allele of -2548G/A polymorphism may be a determinant of cancer development.
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