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Updated: Apr 16, 2026
Development and Evaluation of a Rat Model of Full-Thickness Cartilage Defects
Published on: May 19, 2023
Unpredicted effects of Ankaferd® on cartilage tissue
Cenk Evren1, Mehmet Birol Uğur1, Burhan Yıldırım1
1Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Bulent Ecevit University Zonguldak, Turkey.
Objective:
This study aims to investigate the histopathological changes secondary to the administration of Ankaferd Blood Stopper® (ABS) into the auricular cartilage.
Materials And Methods:
Both of the auricular cartilages of thirty New Zealand rabbits were marked with tattoo ink. A 0.2-cc ABS (study group, n: 30) and 0.2 cc physiological saline (control group, n: 30) were subcutaneously infused into the right auricle and left auricle, respectively. All layers were removed at 14 days.
Results:
The ABS group had significantly higher level of fibrosis, necrosis, foreign body reaction, inflammation, and cartilage degeneration, compared to the controls.
Conclusion:
Our study results showed that ABS administration into a closed cavity led to a significantly increased fibrosis and necrosis in the auricular cartilage.
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