Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Desmosomes01:05

Desmosomes

9.4K
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
9.4K
Cross-reactivity00:42

Cross-reactivity

34.0K
Overview
34.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-acute phase and sequelae management of epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus.

Orphanet journal of rare diseases·2023
Same author

Extensive mucocutaneous, oesophageal and otic lichen planus secondary to nivolumab therapy.

Skin health and disease·2022
Same author

Sex-specific differences in physical health and health services use among Canadian Veterans: a retrospective cohort study using healthcare administrative data.

BMJ military health·2021
Same author

Bruton tyrosine kinase inhibition warrants further study for pemphigus.

The British journal of dermatology·2021
Same author

Blistering severe cutaneous adverse reactions in children: proposal for paediatric-focused clinical criteria.

The British journal of dermatology·2021
Same author

Supportive care in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: an international, multidisciplinary Delphi-based consensus.

The British journal of dermatology·2021

Related Experiment Video

Updated: Apr 16, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

1.6K

Pemphigus and associated comorbidities: a cross-sectional study.

K Heelan1, A L Mahar2, S Walsh1

  • 1Division of Dermatology, ON, Canada.

Clinical and Experimental Dermatology
|March 20, 2015
PubMed
Summary
This summary is machine-generated.

Patients with pemphigus show increased risks of hypothyroidism, inflammatory bowel disease (IBD), and diabetes. Early screening for these conditions is recommended during pemphigus care.

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

11.0K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.7K

Related Experiment Videos

Last Updated: Apr 16, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

1.6K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

11.0K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.7K

Area of Science:

  • Dermatology
  • Autoimmunology
  • Epidemiology

Background:

  • Pemphigus is a rare autoimmune blistering disease.
  • It is associated with various autoimmune and other comorbidities.
  • These include thyroid diseases, rheumatoid arthritis, and systemic lupus erythematosus.

Purpose of the Study:

  • To identify and describe patients with pemphigus who have diagnosed comorbidities.
  • To quantify the risk of developing additional comorbidities in pemphigus patients.

Main Methods:

  • A cross-sectional study was conducted on 295 pemphigus patients at a tertiary referral center.
  • Prevalence rates of 15 comorbid diseases were calculated.
  • Age-standardized prevalence ratios (SPR) were compared to the general Canadian population using Canadian Community Health Survey data.

Main Results:

  • An increased risk of hypothyroidism (SPR=1.53) was observed.
  • A higher incidence of diabetes (SPR=2.20) was noted.
  • An increased risk for inflammatory bowel disease (IBD) (SPR=1.48) was also found.

Conclusions:

  • Pemphigus patients exhibit a higher incidence of hypothyroidism, IBD, and diabetes compared to the general population.
  • Investigating these conditions during pemphigus surveillance is advisable.
  • This proactive approach can aid in comprehensive patient management.