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Late onset post-transfusion hepatitis E developing during chemotherapy for acute promyelocytic leukemia
Kyoko Fuse1, Yuichi Matsuyama, Masato Moriyama
1Department of Hematology, Endocrinology and Metabolism Niigata University Faculty of Medicine, Japan.
Internal Medicine (Tokyo, Japan)
|March 20, 2015
Summary
A leukemia patient developed a prolonged hepatitis E infection after a blood transfusion. Immunosuppression may lead to longer incubation periods for transfusion-transmitted hepatitis E.
Area of Science:
- Hepatology
- Infectious Diseases
- Transfusion Medicine
Background:
- Hepatitis E virus (HEV) infection is a significant concern in transfusion medicine.
- HEV genotype 3 is increasingly recognized as a cause of chronic infection in immunocompromised individuals.
Observation:
- A leukemia patient presented with hepatitis E seven months post-transfusion.
- This latency period is notably longer than typically observed for hepatitis E.
Findings:
- The patient's immunosuppression, due to chemotherapy and steroid use, likely impaired viral clearance.
- High HEV prevalence in Japan poses a risk for transfusion-transmitted infections.
Implications:
- Hepatitis E should be considered an important post-transfusion infection, particularly in immunocompromised populations.
- Immunocompromised patients may experience extended incubation periods for transfusion-transmitted HEV.
- Screening blood products for HEV may be crucial to prevent transfusion-associated hepatitis E.
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