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Related Experiment Videos

Activity-sensing, rate-responsive pacing: improvement in myocardial performance with exercise.

D P Humen, W J Kostuk, G J Klein

    Pacing and Clinical Electrophysiology : PACE
    |January 1, 1985
    PubMed
    Summary

    Activity-sensing pacemakers, using sonic impulses to adjust heart rate, improved anaerobic threshold in patients during exercise. This rate-responsive pacing enhances cardiac output for improved exercise capacity.

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    Area of Science:

    • Biomedical Engineering
    • Cardiology
    • Exercise Physiology

    Background:

    • Pacemakers are crucial for patients needing heart rate regulation.
    • Traditional pacemakers may not adequately adjust to exercise demands.
    • Rate-responsive pacing aims to optimize cardiac output during physical activity.

    Purpose of the Study:

    • To evaluate an activity-sensing pacemaker that uses sonic impulses to adjust pacing rate.
    • To compare activity-sensing, rate-responsive pacing with fixed-rate demand pacing.
    • To assess the impact of these pacing modes on exercise capacity and ventricular function.

    Main Methods:

    • A single-blind, randomized, crossover trial involving six patients (mean age 69 years) post-pacemaker implantation.
    • Comparison of activity-sensing pacing (A) versus fixed-rate demand pacing (D).

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  • Assessment of ventricular function via radionuclide ventriculography and exercise capacity via treadmill testing, including gas exchange analysis.

    • Main Results:

    • Total treadmill duration and maximum oxygen consumption were similar between activity-sensing and fixed-rate pacing modes.
    • The anaerobic threshold was significantly improved with activity-sensing pacing compared to fixed-rate pacing (p < 0.05 for duration, p < 0.01 for oxygen consumption).
    • Ventricular function assessments at rest and during exercise did not show significant differences between the two pacing modes.

    Conclusions:

    • Activity-sensing, rate-responsive pacemakers can improve anaerobic threshold during exercise.
    • This technology may benefit patients requiring enhanced cardiac output during physical exertion.
    • Further research is warranted to fully understand the long-term benefits and applications of sonic impulse-based activity-sensing pacemakers.