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Updated: Apr 16, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
[Results of surgical treatment for pulmonary aspergilloma]
1Service de chirurgie cardiovasculaire et thoracique, hôpital Fann, BP 5035, Dakar, Sénégal.
Introduction:
Aspergilloma results from the development, inside preexisting pulmonary cavities, of aspergillus spores. It is most commonly manifested by hemoptysis. The goal of this retrospective study is to report our surgical experience of this disease.
Patients And Methods:
From January 2004 to December 2008, 35 patients underwent surgery at the same center for pulmonary aspergilloma. We examined the epidemiological, clinical, paraclinical, therapeutic, and outcome data.
Results:
The patients' median age was 43.37 years (range: 20-70 years), 28 were male. The average time to consultation was 19.35 months (1-120 months), and all patients had a history of pulmonary tuberculosis. Hemoptysis was the symptom observed most often, in 54.3% of patients, followed by bronchorrhea. Aspergillus serology was positive for 22 patients. The standard radiological image was found in 20 patients. We performed 14 lobectomies, 1 bilobectomy, 1 segmentectomy, 1 bisegmentectomy, 3 lobectomies with segmentectomies, 1 bilobectomy with segmentectomy, and 14 pleuropneumonectomies. In one case, the pulmonary artery was damaged and repaired. The average duration of intensive care was 3.54 days (2-7 days) and of total hospitalization, 17.33 days (7-48). Complications were: empyema (3 cases), a large air leak (1 case), parietal suppuration (5 cases), and pleural effusion, which was drained (3 cases). There was no postoperative mortality. After 35 months (1-72), one case of recurrent hemoptysis by reinfestation was observed. Three patients died of respiratory failure, one at 6 months and the other two at 1 year after the surgery.
Conclusion:
Despite the associated morbidity, surgical treatment of pulmonary aspergilloma must be proposed systematically to these subjects presenting hemoptysis.
Insights
Surgical intervention for pulmonary aspergilloma, a fungal infection often causing hemoptysis, is recommended despite potential complications. This study reviewed 35 cases, highlighting surgical outcomes and management strategies for this serious lung condition.
Area of Science:
- Pulmonology
- Infectious Diseases
- Thoracic Surgery
Context:
- Pulmonary aspergilloma arises from Aspergillus spores in pre-existing lung cavities.
- Hemoptysis is the most frequent clinical manifestation, necessitating prompt evaluation.
- A history of pulmonary tuberculosis is common among affected individuals.
Purpose:
- To report the surgical experience and outcomes for pulmonary aspergilloma.
- To analyze epidemiological, clinical, and therapeutic data of patients undergoing surgery.
- To evaluate the morbidity and mortality associated with surgical treatment.
Summary:
- A retrospective study of 35 patients (2004-2008) with pulmonary aspergilloma treated surgically.
- Hemoptysis was observed in 54.3% of patients; surgical procedures included lobectomies, segmentectomies, and pleuropneumonectomies.
- Postoperative complications included empyema and air leaks, with no immediate mortality, though late respiratory failure occurred in three patients.
Impact:
- Surgical treatment is deemed essential for patients with pulmonary aspergilloma presenting with hemoptysis.
- The study underscores the importance of surgical intervention despite associated risks.
- Findings contribute to understanding the long-term management and prognosis of pulmonary aspergilloma.
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