Antinuclear antibodies in mice induced by long wave ultraviolet radiation (UVA)

PUVA therapy has been reported to induce antinuclear antibodies (ANA). The generation of ANA following ultraviolet irradiation was studied experimentally in albino mice. When treated with long wave ultraviolet radiation (UVA) from blacklight fluorescent tubes a significant number of animals developed positive ANA titres, whereas no change was noted in groups, treated with PUVA, 8-methoxypsoralen only or medium wave ultraviolet irradiation (UVB) respectively. The tendency for UVA-irradiated mice to develop ANA was stronger when higher ANA titres were compared. UVA induces ANA in mice, and PUVA-induced ANA may be due to the UVA component of this therapy.