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Related Concept Videos

Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Related Experiment Video

Updated: Apr 16, 2026

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
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[Hairy cell leukemia].

S Dietrich1, M Andrulis, T Zenz

  • 1Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.

Der Internist
|March 20, 2015
PubMed
Summary

Hairy cell leukemia, a rare B-cell cancer, is highly treatable due to recent advances. This review covers current knowledge and new targeted therapies for this indolent malignancy.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Context:

  • Hairy cell leukemia (HCL) is a rare, indolent B-cell malignancy.
  • First described in 1958, HCL has a unique clinical and biological profile.
  • Significant progress has been made in understanding HCL pathogenesis.

Purpose:

  • To provide a comprehensive review of hairy cell leukemia.
  • To highlight recent advances in HCL treatment strategies.
  • To focus on novel and targeted therapeutic approaches for HCL.

Summary:

  • Hairy cell leukemia (HCL) is a rare B-cell malignancy with an typically indolent course.
  • Advances in understanding HCL biology have led to highly effective treatments.
  • Current therapeutic strategies are evolving, with a focus on targeted therapies.

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Impact:

  • Improved understanding of HCL biology informs treatment development.
  • Novel targeted therapies offer new hope for patients with hairy cell leukemia.
  • This review provides a foundation for future research in HCL treatment and management.