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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Fabrication of cyclodextrin-templated mesoporous silica for improved dissolution of carbamazepine
Meer Tarique Ali1, Ritesh Fule, Ajay Sav
1Department of Pharmaceutical Science and Technology, Institute of Chemical Technology, Matunga (E), Mumbai, 400019, India.
Abstract:
In the present paper, preparation of mesoporous silica using hydroxy propyl-β-cyclodextrin as a template and its use in solubility enhancement of carbamazepine (CBZ) is reported. The produced mesoporous silica (MS) displayed a large surface area 480.37 m(2)/g and pore volume 0.8041 cm(3)/g. CBZ was loaded on MS and then compressed into a tablet. Dissolution kinetics studies revealed rapid release profiles in comparison to neat crystalline CBZ. Solid-state characterization was done using IR, DSC, PXRD, SEM and TEM, and nitrogen sorption studies. CBZ was found to be in non-crystalline state due to geometric confinement in the nanopore.
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