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Related Concept Videos

Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

264
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
264
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

182
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
182
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

183
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
183
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

141
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
141
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

127
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
127
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

245
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
245

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Related Experiment Video

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Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
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Curcumin implants for continuous systemic delivery: safety and biocompatibility.

Shyam S Bansal1, Hina Kausar, Farrukh Aqil

  • 1Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA.

Drug Delivery and Translational Research
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Summary

Polymeric implants provide sustained curcumin delivery, improving bioavailability and reducing systemic toxicity. Local implantation sites showed minimal inflammation with curcumin implants, indicating good biocompatibility.

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Area of Science:

  • Biomaterials Science
  • Pharmacology
  • Drug Delivery Systems

Background:

  • Curcumin, a potent antioxidant and anti-inflammatory agent, has poor oral bioavailability.
  • Polymeric implants offer a potential solution for sustained systemic delivery of curcumin.

Purpose of the Study:

  • To develop and evaluate the safety and biocompatibility of polymeric implants for continuous systemic curcumin delivery.
  • To assess the release kinetics and local/systemic toxicity of curcumin-loaded implants.

Main Methods:

  • Subcutaneous implantation of polycaprolactone-based curcumin implants in rats.
  • Analysis of hematological parameters, liver/kidney function markers, and local tissue inflammatory response.
  • Monitoring of curcumin release kinetics over 90 days.

Main Results:

  • Curcumin implants demonstrated biphasic release kinetics over 90 days.
  • No significant systemic toxicity observed in hematological or biochemical parameters, except for increased serum phosphorus.
  • Local implantation sites showed reduced foreign body granulomatous reactions with curcumin implants compared to sham implants.

Conclusions:

  • Polymeric implants are a safe and biocompatible system for sustained curcumin delivery.
  • Curcumin implants exhibit minimal systemic toxicity and reduce local inflammatory responses.
  • This delivery system holds promise for enhancing curcumin's therapeutic potential.